Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction.

@article{Scharfstein1996UsefulnessOF,
  title={Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction.},
  author={J S Scharfstein and Dana Abendschein and Paul R. Eisenberg and Dorinda George and Chistopher P Cannon and Richard C. Becker and Burton Sobel and L. Adrienne Cupples and Eugene Braunwald and Joseph Loscalzo},
  journal={The American journal of cardiology},
  year={1996},
  volume={78 5},
  pages={503-10}
}
Thrombin activity is increased in the setting of acute myocardial infarction (AMI) and has been shown to increase further after the administration of thrombolytic therapy for acute infarction. This increase in thrombin activity may play an important role in the 15% to 25% rate of failure to achieve initial reperfusion and in the 5% to 15% rate of early… CONTINUE READING