Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults.

@article{Marzullo2001UsefulnessOD,
  title={Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults.},
  author={Paolo Marzullo and Carolina Di Somma and Katherine L. Pratt and Javad M Khosravi and Anastasia Diamandis and Gaetano Lombardi and Annamaria Colao and Ron G. Rosenfeld},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 7},
  pages={3001-8}
}
The diagnostic approach to acromegaly and GH deficiency frequently includes measurement of several components of the insulin-like growth factor (IGF) system. IGF-I levels are reported to be good predictors of active and cured acromegaly, but are commonly found within the normal age-adjusted range in adult GH-deficient (GHD) patients. Circulating concentrations of IGF-binding protein-3 (IGFBP-3), acid-labile subunit (ALS), and free IGF-I reflect the GH secretory status, but their diagnostic… CONTINUE READING