Usefulness of a new CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections.

@article{Dorfman1997UsefulnessOA,
  title={Usefulness of a new CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections.},
  author={David M Dorfman and Aliakbar Shahsafaei},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1997},
  volume={10 9},
  pages={859-63}
}
We used a new antibody (NCL-CD5-4C7) immunoreactive for CD5-positive cells in paraffin-embedded tissue, with the microwave antigen retrieval method, to analyze a number of well-characterized cases of B-cell and T-cell non-Hodgkin's lymphomas whose CD5 immunoreactivity was documented by immunohistochemical analysis performed on frozen sections and/or flow cytometric immunophenotypic analysis of neoplastic cell suspensions. In all of the cases included in the study, small, reactive T lymphocytes… CONTINUE READING

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