Usefulness, methods and rationale of lymph nodes HPV-DNA investigation in estimating risk of early stage cervical cancer recurrence: a systematic literature review

@article{Noventa2014UsefulnessMA,
  title={Usefulness, methods and rationale of lymph nodes HPV-DNA investigation in estimating risk of early stage cervical cancer recurrence: a systematic literature review},
  author={Marco Noventa and Emanuele Ancona and Erich Cosmi and Carlo Saccardi and Pietro Salvatore Litta and Donato D’Antona and Giovanni Nardelli and Salvatore Gizzo},
  journal={Clinical & Experimental Metastasis},
  year={2014},
  volume={31},
  pages={853-867}
}
Metastatic involvement of pelvic lymph-nodes (LNs), generally found in 0–29.3 % of early stages, is the most important prognostic factor in cervical cancer (CC). However, even in non-metastatic LNs, recurrence rate reaches 10–15 %. The role of HPV-DNA presence in pelvic LNs has been a point of debate in the last two decades. The aim of this systematic review is to collect all available data about LNs HPV-DNA detection in patients affected by early-stage CC in order to elucidate its clinical and… CONTINUE READING

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