Useful Extensions of the Henry Reaction: Expeditious Routes to Nitroalkanes and Nitroalkenes in Aqueous Media

@article{Chandrasekhar2014UsefulEO,
  title={Useful Extensions of the Henry Reaction: Expeditious Routes to Nitroalkanes and Nitroalkenes in Aqueous Media},
  author={S. Chandrasekhar and Annadka Shrinidhi},
  journal={Synthetic Communications},
  year={2014},
  volume={44},
  pages={3008 - 3018}
}
  • S. Chandrasekhar, Annadka Shrinidhi
  • Published 2014
  • Chemistry
  • Synthetic Communications
  • Abstract The products of the Henry nitroaldol reaction from nitromethane and several aldehydes were reduced to the corresponding nitroalkanes with (n-Bu)3SnH in water under microwave irradiation (80 °C/10 min), or dehydrated to the corresponding nitroalkenes with K2CO3 in water (generally 0–5 °C/20 min). Both “one-pot” reactions occur in excellent yields across a range of aliphatic and aromatic (including heteroaromatic) substrates. It seems likely that the deoxygenation of the nitroaldols… CONTINUE READING
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    References

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    1.10 – The Henry (Nitroaldol) Reaction
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