Use of young nude mice for selection of subpopulations of cells with increased metastatic potential from nonsyngeneic neoplasms.

@article{Pollack1982UseOY,
  title={Use of young nude mice for selection of subpopulations of cells with increased metastatic potential from nonsyngeneic neoplasms.},
  author={Vincent A. Pollack and Isaiah Josh Fidler},
  journal={Journal of the National Cancer Institute},
  year={1982},
  volume={69 1},
  pages={137-41}
}
The purpose of these studies was to investigate whether young (3-wk-old) nude mice, which lack functional T-lymphocytes and demonstrate low natural killer cell activity, could serve as in vivo models for the selection of metastatic subpopulations of cells from heterogeneous allogeneic melanomas. Three-week-old BALB/cAnN or N:NIH(S) nude mice received iv injections of single cells harvested from either the B16 or K-1735 melanoma. Individual pulmonary metastases were harvested 4 weeks later and… CONTINUE READING

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