Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections.

@article{Girard2006UseOV,
  title={Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections.},
  author={Francis Colas Pierre Bessi{\`e}re Fabien Flacher Alain Berthoz Girard and Isabelle Batisson and Gabriela Mart{\'i}nez and Cynthia Breton and Jos{\'e}e Harel and John Morris Fairbrother},
  journal={FEMS immunology and medical microbiology},
  year={2006},
  volume={46 3},
  pages={340-50}
}
Using a porcine ileal in vitro organ culture model, we have demonstrated that egg yolk-derived antibodies specific for the attaching and effacing Escherichia coli (AEEC) virulence factors intimin and translocated intimin receptor (Tir), but not those specific for the AEEC-secreted proteins EspA, EspB and EspD, significantly reduced the bacterial adherence of the porcine enteropathogenic E. coli strain ECL1001, formerly 86-1390. Moreover, antibodies specific for intimin and Tir also… CONTINUE READING

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