Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study.

@article{Bowles1990UseOV,
  title={Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study.},
  author={Alfred P. Bowles and Cooley G. Pantazis and William Wansley},
  journal={Journal of neurosurgery},
  year={1990},
  volume={73 2},
  pages={248-53}
}
The authors have evaluated the antiproliferative activity of verapamil, alone or in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in brain-tumor cells. These effects were studied in vitro using four human glioma cell lines and in vivo using glioblastoma multiforme cells transplanted to athymic nude mice. The results showed that verapamil when… CONTINUE READING