Use of ultrasound to facilitate antibiotic diffusion through Pseudomonas aeruginosa alginate.

@article{Williams1995UseOU,
  title={Use of ultrasound to facilitate antibiotic diffusion through Pseudomonas aeruginosa alginate.},
  author={Kendall A. Williams and Heather A. Clark and David G. Allison},
  journal={The Journal of antimicrobial chemotherapy},
  year={1995},
  volume={36 3},
  pages={463-73}
}
The effect of ultrasonic treatment of two pseudomonal alginate samples was studied by investigation of their rheological characteristics and interaction with tobramycin, piperacillin and ciprofloxacin. Whilst exposure to ultrasound at an amplitude of 20 microns for 8 min caused a significant decrease in viscosity of both alginates, molecular fragmentation, as demonstrated by PAGE and gel-permeation chromatography, was minimal. Antibiotic penetration was improved substantially however with… CONTINUE READING