Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine.

@article{Tachibana1993UseOU,
  title={Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine.},
  author={Katsuro Tachibana and Shintaro Tachibana},
  journal={Anesthesiology},
  year={1993},
  volume={78 6},
  pages={1091-6}
}
BACKGROUND Currently available local anesthetics, such as EMLA (eutectic mixture of local anesthetics), have poor skin penetration when administrated topically. As 60 min is needed for EMLA to be fully effective, attempts to accelerate transdermal delivery of a local anesthetic, such as lidocaine, by use of "electrical" and "physical" energy has previously been reported. The current experiment was undertaken to determine whether ultrasonic energy can increase the local anesthetic effect of… CONTINUE READING

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