Use of transgenic mice for understanding the physiology of insulin-like growth factors.

@article{Dercole1996UseOT,
  title={Use of transgenic mice for understanding the physiology of insulin-like growth factors.},
  author={A. Joseph D'ercole and Ping Ye and Gabriel Guti{\'e}rrez-Ospina},
  journal={Hormone research},
  year={1996},
  volume={45 Suppl 1},
  pages={
          5-7
        }
}
Manipulation of the murine genome, either by the insertion of transgenes or by disruption of native genes (so-called gene knockout, accomplished by homologous recombination), and study of the resultant mutant mice have proved invaluable to our understanding of insulin-like growth factor (IGF) physiology. Such investigations have demonstrated that expression of both IGF-I and IGF-II is essential to normal in utero growth of the fetus, while IGF-II is required for normal placental growth. IGF-I… CONTINUE READING
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