Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty

@article{Kelley2014UseOT,
  title={Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty},
  author={Todd C. Kelley and Kimberly K. Tucker and Mary Jo Adams and David F. Dalury},
  journal={Transfusion},
  year={2014},
  volume={54}
}
Tranexamic acid (TXA) is an antifibrinolytic that reduces blood loss and transfusion rates in total joint arthroplasty. Blood loss and allogenic transfusion rates have not been well studied in patients receiving TXA and undergoing bilateral staged total knee arthroplasty (TKA). The purpose was to evaluate the effect of TXA on blood loss, hemoglobin (Hb) changes, and transfusion in patients undergoing staged bilateral TKA. 

Tranexamic Acid Effectively Reduces Blood Loss and Transfusion Rates during Simultaneous Bilateral Total Knee Arthroplasty

Tranexamic acid in bilateral simultaneous TKA effectively reduces blood loss, maintains postoperative Hb and Hct levels, and significantly decreases blood transfusion rates.

A Comparative Study of Blood Loss With and Without Infusion of Tranexamic Acid in Total Knee Replacement

It is concluded that the use of TXA in TKR significantly reduces perioperative blood loss and the need for postoperative blood transfusion without significantly altering the liver and renal functions and coagulation profile of patients.

Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial

It is found that 1 g of topical TXA and 2 G of intravenous TXA were both safe strategies and more effective than routine hemostasis to reduce blood loss and transfusion requirements after primary TKA.

Tranexamic acid combined with iron pathway may significantly decrease the postoperative rate of transfusion after elective total hip and knee replacement

The introduction of tranxemic acid and iron pathway has reduced transfusion rates with improved outcomes and cost reduction and patients who fail to respond to iron treatment should be followed up to ensure no serious pathology.

Tranexamic Acid Reduces Occult Blood Loss, Blood Transfusion, and Improves Recovery of Knee Function after Total Knee Arthroplasty: A Comparative Study

TA could reduce occult blood loss and blood transfusion rate and improve recovery of knee function in patients undergoing TKA.

The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study

1 g IV TXA administered on induction did not significantly reduce the need for blood transfusion, postoperative blood loss, functional scores, or the length of stay in patients undergoing THA.

Comparison of Effects of Tranexamic Acid and Transcollation on Blood Loss in Total Knee Arthroplasty

Use of TXA during primary unilateral TKA is statistically more effective compared with Transcollation using Aquamantys both in terms of mean drop of hemoglobin perioperatively and also in decreasing the proportion of patients that develop perioperative hemoglobin drop of >4 gm/dL, of which the latter finding is also clinically significant.

The Use of Intravenous Tranexamic Acid in Patients Undergoing Total Hip or Knee Arthroplasty: A Retrospective Analysis at a Single Military Institution.

Intravenous TXA is a safe and effective drug to decrease perioperative blood loss and allogeneic transfusion in THA and TKA and there was no increased risk of venous thromboembolism or other complications in the authors' review.

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