Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty

  title={Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty},
  author={Todd C. Kelley and Kimberly K. Tucker and Mary Jo Adams and David F. Dalury},
Tranexamic acid (TXA) is an antifibrinolytic that reduces blood loss and transfusion rates in total joint arthroplasty. Blood loss and allogenic transfusion rates have not been well studied in patients receiving TXA and undergoing bilateral staged total knee arthroplasty (TKA). The purpose was to evaluate the effect of TXA on blood loss, hemoglobin (Hb) changes, and transfusion in patients undergoing staged bilateral TKA. 

Tranexamic Acid Effectively Reduces Blood Loss and Transfusion Rates during Simultaneous Bilateral Total Knee Arthroplasty

Tranexamic acid in bilateral simultaneous TKA effectively reduces blood loss, maintains postoperative Hb and Hct levels, and significantly decreases blood transfusion rates.

A Comparative Study of Blood Loss With and Without Infusion of Tranexamic Acid in Total Knee Replacement

It is concluded that the use of TXA in TKR significantly reduces perioperative blood loss and the need for postoperative blood transfusion without significantly altering the liver and renal functions and coagulation profile of patients.

Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial

It is found that 1 g of topical TXA and 2 G of intravenous TXA were both safe strategies and more effective than routine hemostasis to reduce blood loss and transfusion requirements after primary TKA.

Tranexamic acid combined with iron pathway may significantly decrease the postoperative rate of transfusion after elective total hip and knee replacement

The introduction of tranxemic acid and iron pathway has reduced transfusion rates with improved outcomes and cost reduction and patients who fail to respond to iron treatment should be followed up to ensure no serious pathology.

Tranexamic Acid Reduces Occult Blood Loss, Blood Transfusion, and Improves Recovery of Knee Function after Total Knee Arthroplasty: A Comparative Study

TA could reduce occult blood loss and blood transfusion rate and improve recovery of knee function in patients undergoing TKA.

The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study

1 g IV TXA administered on induction did not significantly reduce the need for blood transfusion, postoperative blood loss, functional scores, or the length of stay in patients undergoing THA.

Comparison of Effects of Tranexamic Acid and Transcollation on Blood Loss in Total Knee Arthroplasty

Use of TXA during primary unilateral TKA is statistically more effective compared with Transcollation using Aquamantys both in terms of mean drop of hemoglobin perioperatively and also in decreasing the proportion of patients that develop perioperative hemoglobin drop of >4 gm/dL, of which the latter finding is also clinically significant.

The Use of Intravenous Tranexamic Acid in Patients Undergoing Total Hip or Knee Arthroplasty: A Retrospective Analysis at a Single Military Institution.

Intravenous TXA is a safe and effective drug to decrease perioperative blood loss and allogeneic transfusion in THA and TKA and there was no increased risk of venous thromboembolism or other complications in the authors' review.



Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta‐analysis of randomized controlled trials

A meta‐analysis was performed to summarize the results of different research studies about tranexamic acid infusion in reducing postoperative blood loss and the number of transfused red cells (RBC) units.

Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee.

It is concluded that two injections of TNA, one given preoperatively and one on deflation of the tourniquet, significantly reduce blood loss without increasing the risk of thromboembolic complications.

Tranexamic acid for control of blood loss in bilateral total knee replacement in a single stage

TEA administered in patients undergoing single stage bilateral TKA helped reduce total blood loss and decreased allogenic blood transfusion requirements, where facilities such as autologous reinfusion might not be available.

Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied

The objective of this study was to assess the effectiveness of tranexamic acid to reduce transfusions in total knee replacement even when a blood conservation program is applied.

One Intraoperative Dose of Tranexamic Acid for Patients Having Primary Hip or Knee Arthroplasty

One 20-mg per kg intraoperative dose of tranexamic acid reduced the perioperative decrease in hemoglobin and red blood cell transfusion rates in patients having TKA and THA compared with those of a similar cohort of patients in whom the protocol was not used.

Tranexamic Acid Radically Decreases Blood Loss and Transfusions Associated with Total Knee Arthroplasty

It is concluded that short-term tranexamic acid therapy significantly reduces TKA-associated blood loss and transfusion requirements without increasing thromboembolic complications.

Use of Intravenous Tranexamic Acid to Reduce Allogeneic Blood Transfusion in Total Hip and Knee Arthroplasty: A Meta-analysis

Intravenous tranexamic acid appears effective and safe in reducing allogeneic blood transfusion and blood loss in total hip and knee arthroplasty and whether it might increase the risk of thromboembolic complications.

Effectiveness and safety of tranexamic acid administration during total knee arthroplasty

This data indicates that the administration of tranexamic acid is associated with a decrease in the number of red blood cell units transfused, but concerns about its safety have hindered its broader use.

Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients.

The number of patients receiving blood transfusion and the number of blood units transfused were reduced to one-third in the treated group, and mean postoperative Hb concentrations were significantly higher after prophylaxis.

Efficacy and Safety of Tranexamic Acid in Control of Bleeding Following TKR: A Randomized Clinical Trial

Patients had unilateral / bilateral cemented TKA using combined spinal and epidural anaesthesia and received tranexamic acid, an antifibrinolytic agent which decreases the total blood loss.