Use of topiramate in childhood generalized seizure disorders.

  title={Use of topiramate in childhood generalized seizure disorders.},
  author={James W. Wheless},
  journal={Journal of child neurology},
  volume={15 Suppl 1},
Topiramate is a sulfamate derivative of the naturally occurring monosaccharide D-fructose. It was initially approved in the United States as adjunctive therapy for partial seizures in 1997. However, there is increasing evidence that it is effective in the treatment of generalized seizures and epilepsy syndromes. Initially, open-label studies using topiramate as add-on therapy in children with refractory generalized seizure types were performed. These showed improvement in patients with the… CONTINUE READING


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