Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene.

@article{Dallas1994UseOT,
  title={Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene.},
  author={Cham E. Dallas and Xiang Mei Chen and Srinivasa Muralidhara and Peter Varkonyi and Randall L. Tackett and James V. Bruckner},
  journal={Environmental research},
  year={1994},
  volume={67 1},
  pages={54-67}
}
Tissue disposition of perchloroethylene (PCE) was determined experimentally in two mammalian species of markedly different size in order to derive input parameters for the development of a physiologically based pharmacokinetic (PBPK) model, which could forecast the disposition of PCE in each species. Male Sprague-Dawley rats and male beagle dogs received a single bolus of 10 mg PCE/kg body wt in polyethylene glycol 400 by gavage. Serial samples of brain, liver, kidney, lung, heart, skeletal… CONTINUE READING

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