Use of thymosin β15 as a urinary biomarker in human prostate cancer

@article{Hutchinson2005UseOT,
  title={Use of thymosin $\beta$15 as a urinary biomarker in human prostate cancer},
  author={Lloyd M Hutchinson and Eric L. Chang and Christian M. Becker and Mei-Chiung Shih and Mark J. Brice and William DeWolf and Sandra M Gaston and Bruce R. Zetter},
  journal={The Prostate},
  year={2005},
  volume={64}
}
Additional prostate cancer (CaP) biomarkers are needed to increase the accuracy of diagnosis and to identify patients at risk of recurrence. In tissue‐based assays, thymosin β15 (Tβ15) has been linked to an aggressive CaP phenotype and correlated with future tumor recurrence. We hypothesized that Tβ15 may have clinical utility in biological fluids. 
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References

SHOWING 1-10 OF 36 REFERENCES
Thymosin beta-15 predicts for distant failure in patients with clinically localized prostate cancer-results from a pilot study.
TLDR
It is demonstrated that Tbeta15 staining intensity may be a potentially important marker to identify high-risk patients with moderately differentiated, clinically localized prostate cancer. Expand
Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer
TLDR
Transfection of antisense thymosin β15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Expand
Elevated serum chromogranin A precedes prostate-specific antigen elevation and predicts failure of androgen deprivation therapy in patients with advanced prostate cancer.
TLDR
For patients with advanced prostate cancer receiving ADT, serum CgA may be a useful tumor marker that precedes PSA elevation, which signals ultimate treatment failure and may have clinical implications for implementation of novel therapies. Expand
Biochemical outcome after radical prostatectomy among men with normal preoperative serum prostate‐specific antigen levels
TLDR
The authors compared the risk of biochemical failure after radical prostatectomy (RP) between men with normal PSA levels and men with elevated PSA Levels to find out if normal levels are associated with better outcomes. Expand
Predictors for biopsy outcome in the European Randomized Study of Screening for Prostate Cancer (Rotterdam Region)
In the European Randomized Study of Screening for Prostate Cancer (ERSPC, Rotterdam region), men aged 55–74 years are screened for prostate cancer by prostate‐specific antigen (PSA) sampling, digitalExpand
Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer
TLDR
The authors calculated the probability at birth of having a diagnosis of prostate cancer within a man's life to be 8.8% and subtracted the incidence of microscopic Stage A cancers too small to ever be clinically significant. Expand
Impact of preoperative serum PSA level from 0 to 10 ng/ml on pathological findings and disease‐free survival after radical prostatectomy
TLDR
To determine the impact of various preoperative serum prostate specific antigen (PSA) levels in the range from 0.1 to 10 ng/ml on pathological stage and disease‐free survival after radical prostatectomy, a large number of patients were referred for surgery. Expand
Prostate-specific membrane antigen levels in sera from healthy men and patients with benign prostate hyperplasia or prostate cancer.
TLDR
It is confirmed that PSMA is not a specific biomarker for prostate cancer and that a variety of normal and diseased tissue may contribute to the serum levels of PSMA, and found elevated serum PSMA in healthy females, and the levels increased with age. Expand
Thymosin β15 expression in tumor cell lines with varying metastatic potential
TLDR
Thymosin β15 was upregulated in the highly metastatic mouse lung and human breast cancer cell lines in comparison to the nonmetastatic counterparts, and may be a useful marker to predict metastatic potential of certain human cancers. Expand
Time trends in clinical risk stratification for prostate cancer: implications for outcomes (data from CaPSURE).
TLDR
A significant downward risk migration has occurred over time in Gleason score and PSA, and this shift is most likely attributable to changes in practice patterns with respect to screening and pathological grading. Expand
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3
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