Use of three-dimensional collagen gels to study mechanotransduction in T47D breast epithelial cells

@article{Wozniak2005UseOT,
  title={Use of three-dimensional collagen gels to study mechanotransduction in T47D breast epithelial cells},
  author={Michele A. Wozniak and Patricia J. Keely},
  journal={Biological Procedures Online},
  year={2005},
  volume={7},
  pages={144 - 161}
}
Several pathological and disease conditions can alter the mechanical properties of the extracellular matrix (ECM). Conversely, some diseases may arise from changes in the density or rigidity of the ECM. This necessitates the use and development of in vitro models to understand how both biophysical and biochemical signals regulate complex cellular behaviors. T47D breast epithelial cells will differentiate into duct-like tubules when cultured in a floating three-dimensional (3D) collagen gel, but… CONTINUE READING
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