Use of thiazolidinediones and fracture risk.

  title={Use of thiazolidinediones and fracture risk.},
  author={C R Meier and Marius E. Kraenzlin and Michael Bodmer and Susan Sara Jick and Hershel Jick},
  journal={Archives of internal medicine},
  volume={168 8},
BACKGROUND Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss. METHODS This study examines the association between the use of thiazolidinediones or other oral antidiabetic drugs and the risk of fracture. This nested case-control analysis uses the UK General Practice Research Database, including case patients with fracture aged 30 to 89 years with an incident fracture diagnosis between January 1994 and December 2005 and control… CONTINUE READING