Use of the urine cortisol-to-creatinine ratio for monitoring dogs with pituitary-dependent hyperadrenocorticism during induction treatment with mitotane (o,p'-DDD).

Abstract

OBJECTIVE To determine whether the urine cortisol-to-creatinine ratio (UCCR) could replace the ACTH stimulation test in monitoring effectiveness of mitotane induction treatment in dogs with pituitary-dependent hyperadrenocorticism (PDH). ANIMALS 15 dogs with PDH. PROCEDURE All 15 dogs were given an induction dose of mitotane (o,p'-DDD: 35 to 50 mg/kg of… (More)

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