Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.

@article{Taichman2002UseOT,
  title={Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.},
  author={Russell S. Taichman and Carlton R. Cooper and Evan Keller and Kenneth J. Pienta and Norton S Taichman and L. McCauley},
  journal={Cancer research},
  year={2002},
  volume={62 6},
  pages={1832-7}
}
Neoplasms have a striking tendency to metastasize or "home" to bone. Hematopoietic cells also home to bone during embryonic development, where evidence points to the chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12; expressed by osteoblasts and endothelial cells) and its receptor (CXCR4) as key elements in these processes. We hypothesized that metastatic prostate carcinomas also use the SDF-1/CXCR4 pathway to localize to the bone. To test this, levels of CXCR4 expression were determined… CONTINUE READING
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