Use of the selective benzodiazepine-1 (BZ-1) ligand [3H]2-oxo-quazepam (SCH 15–725) to localize BZ-1 receptors in the rat brain

  title={Use of the selective benzodiazepine-1 (BZ-1) ligand [3H]2-oxo-quazepam (SCH 15–725) to localize BZ-1 receptors in the rat brain},
  author={James P. Yezuita and R Tyler Mccabe and Allen Barnett and Louis C. Iorio and James K. Wamsley},
  journal={Neuroscience Letters},
Characterization of the Binding and Comparison of the Distribution of Benzodiazepine Receptors Labeled with [3H]Diazepam and [3H]Alprazolam
Competition studies, using various ligands to inhibit both [ 3H]diazepam and [3H]alprazolam indicated that these two compounds bind to the tissue sections as typical benzodiazepine drugs and apparently do not overlap onto other subtypes of receptors.
GABAA-benzodiazepine receptors: demonstration of pharmacological subtypes in the brain.
The GABAA receptor is a ligand-gated chloride ion channel that mediates the majority of rapid-acting inhibitory synapses in the central nervous system and mediate the action of barbiturates, steroid anesthetics, and possibly ethanol to enhance GAB AA receptor function at the membrane level.
Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA‐L study in the rat
This study demonstrates that the major output of the nociceptive spino(trigemino)‐parabrachio‐CeLC pathway is to the SId, suggesting that the CeLC–SId pathway could have an important role in anxiety, aversion and genesis of fear in response to noxious stimuli.


Binding of a radiolabeled triazolopyridazine to a subtype of benzodiazepine receptor in the rat cerebellum.
Describing the binding of radiolabeled CL to membranes from rat cerebellum and suggesting that it binds to the Type 1 BZ receptor in a manner different from that of a BZ drug such as FLU suggest that TPZ drugs may affect the GABA receptor complex in a different or perhaps less extensive way than the BZs.
Ethyl β-carboline-3-carboxylate shows differential benzodiazepine receptor interaction
It is reported here that β-CCE, in contrast to Benzodiazepines, can distinguish clearly between benzodiazepine receptors in cerebellum and hippocampus, which strongly indicates that benzodiazine receptors are not a single class of non-interacting entities.
Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.
The results of this study may help explain the physiological differences between the benzodiazepine and triazolopyridazine drugs and should point out target sites in the brain for additional studies of the apparently two different receptors.
Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors
Benzodiazepine receptors: Cellular and behavioral characteristics