Use of the rat pancreatic CA20948 cell line for the comparison of radiolabelled peptides for receptor-targeted scintigraphy and radionuclide therapy.

@article{Bernard2000UseOT,
  title={Use of the rat pancreatic CA20948 cell line for the comparison of radiolabelled peptides for receptor-targeted scintigraphy and radionuclide therapy.},
  author={Bert F. Bernard and Eric P. Krenning and Wouter A. P. Breeman and Theo J. Visser and Willem H. Bakker and Ananth Srinivasan and M. M. Th. de Jong},
  journal={Nuclear medicine communications},
  year={2000},
  volume={21 11},
  pages={1079-85}
}
We have evaluated the usefulness of the rat pancreatic CA20948 tumour as an in vitro cell culture model and as an in vivo model in Lewis rats comparing different radiolabelled peptides for receptor-targeted scintigraphy. In vitro the receptor-specific uptake and internalization of different radiolabelled analogues of somatostatin, bombesin, substance P and cholecystokinin were demonstrated. Analogues were selected based on high-affinity binding to their respective receptors. Their uptake and… CONTINUE READING

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