Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment.

@article{Worthington2004UseOT,
  title={Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment.},
  author={J. T. Worthington and Helen O McCarthy and Eimear Barrett and Catherine Adams and Tracy Robson and David G. Hirst},
  journal={The journal of gene medicine},
  year={2004},
  volume={6 6},
  pages={673-80}
}
BACKGROUND Inducible nitric oxide synthase (iNOS) gene therapy has been identified as a potential anti-tumour strategy. A major problem common to most gene therapy strategies is targeting of treatment to the tumour volume. In this study we report on the use of the X-ray-inducible WAF1 promoter to achieve targeting of iNOS expression to the tumour volume. METHODS A WAF1/iNOS/liposome complex was injected directly into RIF-1 and HT29 tumours in mice. A 4 Gy dose of X-rays was applied to induce… CONTINUE READING

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