Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis.

@article{Balaban2003UseOT,
  title={Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis.},
  author={Naomi Davis Balaban and Andrea Giacometti and Oscar Cirioni and Yael Gov and Roberto Ghiselli and Federico Mocchegiani and Claudio Viticchi and Maria Simona Del Prete and Vittorio Saba and Giorgio Scalise and G. Dell'acqua},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={187 4},
  pages={
          625-30
        }
}
Staphylococcus epidermidis is a frequent cause of infections associated with foreign bodies and indwelling medical devices. The bacteria are capable of surviving antibiotic treatment through encapsulation into biofilms. RNAIII-inhibiting peptide (RIP) is a heptapeptide that inhibits S. aureus pathogenesis by disrupting quorum-sensing mechanisms. In this study, RIP inhibited drug-resistant S. epidermidis biofilm formation through a mechanism similar to that evidenced for S. aureus. RIP is… CONTINUE READING
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