Use of the polymerase chain reaction to analyse sequence variation within a major neutralizing epitope of glycoprotein B (gp58) in clinical isolates of human cytomegalovirus.

@article{Darlington1991UseOT,
  title={Use of the polymerase chain reaction to analyse sequence variation within a major neutralizing epitope of glycoprotein B (gp58) in clinical isolates of human cytomegalovirus.},
  author={John Darlington and Michael Super and Ketan B. Patel and Jane E. Grundy and Paul D. Griffiths and Vincent C Emery},
  journal={The Journal of general virology},
  year={1991},
  volume={72 ( Pt 8)},
  pages={1985-9}
}
The heterogeneity of low passage human cytomegalovirus (HCMV) strains was determined by HindIII typing of 28 clinical isolates from transplant patients. These data have shown that, in general, each patient's strain has a unique restriction profile, usually comprising combinations of HindIII sites present in one or more of the tissue culture-adapted strains AD169, Towne and Davis. To map sequence changes in a more refined manner we performed detailed analyses of 33 low passage clinical isolates… CONTINUE READING

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