Use of the nuclear receptor PXR to predict drug interactions.

@article{Moore2000UseOT,
  title={Use of the nuclear receptor PXR to predict drug interactions.},
  author={Johnetta Moore and Steven Anthony Kliewer},
  journal={Toxicology},
  year={2000},
  volume={153 1-3},
  pages={
          1-10
        }
}
We recently cloned the human, rabbit, rat, and mouse orthologs of a novel member of the steroid/retinoid/thyroid hormone receptor family, which we have named the Pregnane X Receptor (PXRs). The discovery and characterization of PXR has led to an increased understanding of the molecular basis of many drug-drug interactions as well as a better understanding of xenobiotic metabolism in general. The key insights into PXR action was the finding that this nuclear receptor is linked to regulation of… CONTINUE READING
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