Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity.

Abstract

Thioridazine is metabolized in humans by CYP2D6 to mesoridazine, which is an active metabolite. Two or more CYP2D6 substrates are seldom given simultaneously to elderly patients because potentially dangerous metabolic interactions may occur. It may be valuable to know the CYP2D6 metabolic capacity of such patients to avoid drug interactions, which depend on… (More)

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Cite this paper

@article{Llerena2000UseOT, title={Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity.}, author={Adri{\'a}n Llerena and Roland Berecz and Alfredo de la Rubia and M J Norberto and J. Benitez}, journal={Therapeutic drug monitoring}, year={2000}, volume={22 4}, pages={397-401} }