Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.

@article{Galleni1994UseOT,
  title={Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.},
  author={Moreno Galleni and Nicola Franceschini and Birgit Quinting and Lanfranco 7 Fattorini and G. Orefici and Arduino Oratore and Jean Marie Fr{\`e}re and Gianfranco Amicosante},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 7},
  pages={1608-14}
}
Sixteen different compounds usually considered beta-lactamase stable or representing potential beta-lactam inhibitors and inactivators were tested against the beta-lactamase produced by Mycobacterium fortuitum. The compounds exhibiting the most interesting properties were BRL42715, which was by far the best inactivator, and CGP31608 and ceftazidime, which were not recognized by the enzyme. These compounds thus exhibited adequate properties for fighting mycobacterial infections. Although… CONTINUE READING
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