Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.

Abstract

PURPOSE To evaluate ability of the University of California Los Angeles Integrated Staging System (UISS) to stratify patients with localized and metastatic renal cell carcinoma (RCC) into risk groups in an international multicenter study. PATIENTS AND METHODS 4,202 patients from eight international academic centers were classified according to the UISS, which combines TNM stage, Fuhrman grade, and Eastern Cooperative Oncology Group performance status. Distribution of the UISS categories was assessed in the overall population and in each center. RESULTS The UISS stratified both localized and metastatic RCC into three different risk groups (P <.001). For localized RCC, the 5-year survival rates were 92%, 67%, and 44% for low-, intermediate-, and high-risk groups, respectively. A trend toward a higher risk of death was observed in all centers for increasing UISS risk category. For metastatic RCC, the 3-year survival rates were 37%, 23%, and 12% for low-, intermediate-, and high-risk groups, respectively; in 6 of 8 centers, a trend toward a higher risk of death was observed for increasing UISS risk category. A greater variability in survival rates among centers was observed for high-risk patients. CONCLUSION This study defines the general applicability of the UISS for predicting survival in patients with RCC. The UISS is an accurate predictor of survival for patients with localized RCC applicable to external databases. Although the UISS may be useful for patients with metastatic RCC, it may be less accurate in this subset of patients due to the heterogeneity of patients and treatments.

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@article{Patard2004UseOT, title={Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.}, author={Jean-Jacques Patard and Hyung-Lae Kim and John S. Lam and Frederick J. Dorey and Allan J. Pantuck and Amnon Zisman and Vincenzo Ficarra and Ken-ryu Han and Luca Cindolo and Alexandre de la Taille and Jacques Tostain and Walter Artibani and Colin Dinney and Christopher G. Wood and David A. Swanson and Claude Cl{\'e}ment Abbou and Bernard Lobel and Peter F. A. Mulders and Dominique K. Chopin and Robert Alan Figlin and Arie S. Belldegrun}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2004}, volume={22 16}, pages={3316-22} }