Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat.

@article{Grossman1986UseOT,
  title={Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat.},
  author={Scott J. Grossman and David J. Jollow},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1986},
  volume={14 6},
  pages={689-91}
}
The retention of tritium in urinary p-aminophenol and p-hydroxyacetanilide was determined following the administration of p-3H-aniline or p-3H-acetanilide to rats. When p-3H-aniline (1.5 mmol/kg, ip) was given to rats, the retention of tritium in urinary p-aminophenol and p-hydroxyacetanilide was 15% and 38%, respectively. Similar results were obtained following the administration of p-3H-acetanilide (1.5 mmol/kg). However, when p-3H-acetanilide was given to rats which had been pretreated with… CONTINUE READING
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