Use of the Hollow Fiber Assay to Evaluate Agents That Target the Tumor Neovasculature.

@article{Cooper2016UseOT,
  title={Use of the Hollow Fiber Assay to Evaluate Agents That Target the Tumor Neovasculature.},
  author={Patricia A. Cooper and Steven Shnyder},
  journal={Methods in molecular biology},
  year={2016},
  volume={1430},
  pages={
          375-86
        }
}
In vivo preclinical assays are required to screen potential agents that target the tumor vasculature. Here a hollow fiber-based assay for the quantification of neovasculature in the presence or absence of an agent that potentially targets tumor neovasculature is described. The neovasculature is developed as a consequence of the presence of tumor cells encapsulated in hollow fibers, which are transplanted sub-cutaneously in the dorsal flanks of mice. 
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