Use of the DBD-FISH technique for detecting DNA breakage in response to high doses of X-rays.

Abstract

The aim of this study was to generate a dose-response curve using the DNA breakage detection-fluorescent in situ hybridization (DBD-FISH) test as a biomarker of initial genetic effects induced by high doses of X-rays. A dose-response curve was obtained by measuring the ex vivo responses to increasing doses (0-50 Gy) of X-rays in the peripheral blood… (More)
DOI: 10.1007/s00411-014-0555-4

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