Use of the BioDis to generate a physiologically relevant IVIVC.

@article{Klein2008UseOT,
  title={Use of the BioDis to generate a physiologically relevant IVIVC.},
  author={Sandra Klein and Markus W Rudolph and Brigitte Skalsky and H Petereit and Jennifer B. Dressman},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2008},
  volume={130 3},
  pages={216-9}
}
In the last decades there has been continual interest in site-specific delivery to the colon. Recently, new types of site-specific delivery formulations have been developed for the treatment of ulcerative colitis and other colon related diseases. The aim of the present study was to establish a physiologically relevant IVIVC for two prototypes using a prospective in vitro study. Caffeine, a drug being absorbed along the entire gastrointestinal tract, was selected as a model drug. USP apparatus 3… CONTINUE READING