Use of the Øie-Tozer model in understanding mechanisms and determinants of drug distribution.

  title={Use of the \Oie-Tozer model in understanding mechanisms and determinants of drug distribution.},
  author={Nigel J. Waters and Franco Lombardo},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={38 7},
Volume of distribution (VD) is a key pharmacokinetic property that together with clearance determines the half-life or residence time of drug in the body. It is commonly expressed as steady-state volume of distribution VD(ss) with a physiological basis for its understanding developed by Øie and Tozer in 1979. The Øie-Tozer equation uses terms for plasma protein binding (f(up)), tissue binding (f(ut)), and the extravascular/intravascular ratio of albumin as well as constants for the volumes of… CONTINUE READING

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