Use of testosterone to prevent cyclophosphamide-induced azoospermia.

  title={Use of testosterone to prevent cyclophosphamide-induced azoospermia.},
  author={Antonia Masala and Rossana Faedda and Sergio Alagna and Antonio Satta and Giusy Chiarelli and Pier Paolo Rovasio and R. Ivaldi and Maddalena Taras and Elena Lai and Eric Bartoli},
  journal={Annals of internal medicine},
  volume={126 4},
Several cytotoxic agents used to treat neoplastic or immunologic diseases may alter endocrine function in humans [1-5]. In particular, gonadal failure with azoospermia, amenorrhea, or anovulatory cycles has been reported in patients treated for various diseases [1-3]. Cyclophosphamide, an alkylating drug, is widely used as an antineoplastic or immunosuppressive agent. Severe gonadal failure with transient or permanent azoospermia is found in 50% to 90% of men treated with cyclophosphamide [6, 7… CONTINUE READING


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