Use of tension measurements to delineate the mode of action of vasodilators.

Direct experimental procedures to delineate the modes of inhibition of drugs on vascular smooth muscle contractility are described. In isolated rabbit aortic strips, high concentrations of KCl and norepinephrine induce sustained contractions that depend upon Ca2+ influx mediated by selective activation of voltage-dependent and receptor-linked Ca2+ channels… CONTINUE READING