Use of synthetic signal sequences to explore the protein export machinery.

@article{Clrico2008UseOS,
  title={Use of synthetic signal sequences to explore the protein export machinery.},
  author={Eugenia M. Cl{\'e}rico and Jenny L. Maki and Lila M. Gierasch},
  journal={Biopolymers},
  year={2008},
  volume={90 3},
  pages={307-19}
}
The information for correct localization of newly synthesized proteins in both prokaryotes and eukaryotes resides in self-contained, often transportable targeting sequences. Of these, signal sequences specify that a protein should be secreted from a cell or incorporated into the cytoplasmic membrane. A central puzzle is presented by the lack of primary structural homology among signal sequences, although they share common features in their sequences. Synthetic signal peptides have enabled a… CONTINUE READING