Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover.

@article{Patterson2002UseOS,
  title={Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover.},
  author={Bruce W. Patterson and Bettina Mittendorfer and Nizar Elias and Raj Satyanarayana and Samuel Klein},
  journal={Journal of lipid research},
  year={2002},
  volume={43 2},
  pages={223-33}
}
Tracer methods for VLDL-TG kinetics vary in their ability to account for the effect of tracer recycling, which can influence the calculation of VLDL-TG fractional catabolic rates (FCRs). We evaluated a novel approach, involving stable isotopically labeled glycerol or palmitate tracers in conjunction with compartmental modeling, for measuring VLDL-TG kinetics in normolipidemic human subjects. When administered as a bolus simultaneously, both tracers provided identical VLDL-TG FCRs when the data… CONTINUE READING