Use of solubility parameters of drug and vehicle to predict flux through skin.

@article{Sloan1986UseOS,
  title={Use of solubility parameters of drug and vehicle to predict flux through skin.},
  author={Kenneth Berry Sloan and Suzanne A. M. Koch and Kevin G. Siver and Franklin P. Flowers},
  journal={The Journal of investigative dermatology},
  year={1986},
  volume={87 2},
  pages={
          244-52
        }
}
The solubilities of theophylline in, and fluxes through skin from, isopropyl myristate, octanol, dimethylformamide, propylene glycol, ethylene glycol, and formamide have been determined experimentally. Values for experimental permeability coefficients (Kp) corresponding to the respective fluxes were determined from, flux/solubility = Kp, which were then compared with values for the respective theoretical partition coefficients (PC) calculated from the known solubility parameters for the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Similar Papers

Loading similar papers…