Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs.

@article{Fossati2008UseOS,
  title={Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs.},
  author={Lina Fossati and Rachel Dechaume and Emmanuel Hardillier and Delphine Chevillon and Colette Pr{\'e}vost and S{\'e}bastien Bolze and Nathalie Maubon},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={360 1-2},
  pages={148-55}
}
The most commonly used method to assess intestinal permeability is the measurement of compound flux across a Caco-2 cells monolayer by using Hanks balanced salt solution (HBSS)-like buffers. Nevertheless, lipophilic acid drugs are poorly or not at all soluble in these types of buffers and their adsorption on the transwell plate is commonly observed. To reduce adsorption and increase solubility, permeability assays need to be developed in conditions other than classic conditions for lipophilic… CONTINUE READING

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