Use of silk protein, sericin, as a sustained-release material in the form of a gel, sponge and film.

@article{Nishida2010UseOS,
  title={Use of silk protein, sericin, as a sustained-release material in the form of a gel, sponge and film.},
  author={Ayumu Nishida and Masaki Yamada and Takanori Kanazawa and Yuuki Takashima and Kiyohisa Matsumoto-shi Ouchi and Hiroshi Okada},
  journal={Chemical & pharmaceutical bulletin},
  year={2010},
  volume={58 11},
  pages={
          1480-6
        }
}
To evaluate the usability of silk protein (sericin, SC) as a sustained-release material, the physicochemical properties of SC and the release profiles of model drugs from SC gel, sponge and film were studied. Heat aids the dissolution of SC. The molecular weight of SC tended to decrease as the heating temperature and heating time increased. The gel and sponge formed by SC were moldable and consisted of high molecular weight SC polymers (250 kDa and about 400 kDa). SC film was easily broken and… CONTINUE READING

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