Use of siRNAs and antisense oligonucleotides against survivin RNA to inhibit steps leading to tumor angiogenesis.

@article{Coma2004UseOS,
  title={Use of siRNAs and antisense oligonucleotides against survivin RNA to inhibit steps leading to tumor angiogenesis.},
  author={S{\'i}lvia Coma and V{\'e}ronique No{\'e} and Cinzia Lavarino and Jaume Ad{\'a}n and M. Rubio Rivas and Mariana L{\'o}pez-Matas and Roser Pagan and Francesc Mitjans and Sen{\'e}n Vilar{\'o} and Jaume Piulats and Carlos Ciudad},
  journal={Oligonucleotides},
  year={2004},
  volume={14 2},
  pages={100-13}
}
The antiapoptotic protein survivin is an attractive target in cancer therapy because it is expressed differently in tumors and normal tissues and it is potentially required for cancer cells to remain viable. Given that survivin is also overexpressed in endothelial cells (ECs) of newly formed blood vessels found in tumors, its RNA targeting might compromise EC viability and interfere with tumor angiogenesis. We used two antisense strategies against survivin expression, antisense oligonucleotides… CONTINUE READING

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