Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism.

@article{Hviid2013UseOS,
  title={Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism.},
  author={Anders Hviid and Mads Melbye and Bj{\"o}rn Pasternak},
  journal={The New England journal of medicine},
  year={2013},
  volume={369 25},
  pages={
          2406-15
        }
}
BACKGROUND Studies have raised concern about an association between the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and an increased risk of autism spectrum disorders in the offspring. METHODS We conducted a cohort study of all singleton live births in Denmark from 1996 through 2005 (626,875 births), with follow-up through 2009. Using Danish population registries, we linked information on maternal use of SSRIs before and during pregnancy, autism spectrum disorders… Expand
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176 Citations

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Risk of autism spectrum disorder in offspring following paternal use of selective serotonin reuptake inhibitors before conception: a population-based cohort study
TLDR
The mildly increased risk of ASD in the offspring associated with paternal SSRIs use before conception may be attributable to paternal underlying psychiatric indications related to SSRI use or other unmeasured confounding factors. Expand
In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder
TLDR
Evidence that in utero exposure to SSRIs increases a child’s risk associated with ASD is found and these results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers. Expand
Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study.
TLDR
Prenatal SSRI exposure was associated with increased rates of depression diagnoses in early adolescence but not with ASD or ADHD, and these findings must be balanced against the substantial adverse consequences of untreated maternal depression. Expand
Association Between Maternal Use of SSRI Medications and Autism in Their Children.
TLDR
Examination of pregnancies from 1998 to 2009 in the Quebec Pregnancy/Children Cohort database that resulted in children with autism spectrum disorder (ASD) as the primary outcome concluded that second- or third-trimester exposure to SSRIs was associated with increased risk for ASD. Expand
Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring.
TLDR
Exposure to SSRIs during pregnancy was associated with an increased risk of speech/language disorders in offspring up to early adolescence, and this finding may have implications for understanding associations betweenSSRIs and child development. Expand
Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children
TLDR
In children born to mothers receiving public drug coverage in Ontario, Canada, in utero serotonergic antidepressant exposure compared with no exposure was not associated with autism spectrum disorder in the child, and the previously observed association may be explained by other factors. Expand
Safety of Selective Serotonin Reuptake Inhibitors in Pregnancy: A Review of Current Evidence
TLDR
It is recommended that pregnant women exposed to any SSRI in early pregnancy be offered options for prenatal diagnosis through ultrasound examinations and fetal echocardiography to detect the presence of birth defects. Expand
Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children.
TLDR
Use of antidepressants, specifically selective serotonin reuptake inhibitors, during the second and/or third trimester increases the risk of ASD in children, even after considering maternal depression. Expand
Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children.
To the Editor The register-based cohort study by Boukhris et al1 investigating the association between prenatal antidepressant use and risk of autism spectrum disorders (ASD) in the offspring was… Expand
Autism spectrum disorders: weighing the risk of SSRI exposure in pregnancy
TLDR
This study failed to demonstrate that SSRI exposure during pregnancy is safe in terms of child development outcomes, as an increased risk of ASDs cannot be completely ruled out. Expand
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