Use of repeated CO2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanate.

@article{Wong1985UseOR,
  title={Use of repeated CO2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanate.},
  author={Ka Leung Wong and Meryl H. Karol and Yves Alarie},
  journal={Journal of toxicology and environmental health},
  year={1985},
  volume={15 1},
  pages={137-48}
}
Guinea pigs were exposed to 1.4 ppm toluene diisocyanate (TDI) for 3 h/d on 5 consecutive days to produce chemical bronchitis. Following these exposures, the ventilatory response of the animals to challenge with 10% CO2 was greatly diminished. Response recovered during the next 40 d. In contrast, animals exposed to 0.02 ppm TDI daily for 70 d showed no change in ventilatory response to challenge with 10% CO2, nor did control animals which were not exposed to TDI. These results indicated both… CONTINUE READING