Use of repaglinide on a pregnant woman during embryogenesis

  title={Use of repaglinide on a pregnant woman during embryogenesis},
  author={M. A. Mollar-Puchades and Alexandra Mart{\'i}n-Cort{\'e}s and A Perez-Calvo and Cesar Diaz-Garcia},
In the past few years, oral antihyperglycaemic agents have been considered as an alternative to insulin therapy in the treatment of gestational diabetes. There is still little information available on the safety of these drugs during pregnancy, but there have been several studies published regarding their use. Here we report on the case of a woman who took repaglinide up to the seventh week of pregnancy. Delivery occured with no complications and the newborn showed no malformations. Further… 
Review of metformin and glyburide in the management of gestational diabetes
Glyburide and metformin appear to be safe and effective to manage blood glucose in patients with gestational diabetes who prefer to not utilize insulin or who cannot afford insulin therapy.
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Metformin is seen by some as the treatment of choice where weight gain is an issue, providing that the unanswered questions over the long-term safety of oral agents have been discussed.
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  • Medicine
    American journal of cardiovascular drugs : drugs, devices, and other interventions
  • 2007
Repaglinide is a compound that can be used in both mono- and combination therapy for the treatment of both fasting and postprandial hyperglycemia in patients with T2DM and is associated with less weight gain than sulphonylureas and the glitazones.
Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).
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  • 2011
Since a higher transfer rate of repaglinide was observed in fetal-to-maternal than maternal- to-fetal direction, active transport by OATP-transporters may be an important factor in fetal exposure to repaglinside.
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  • 2005
The bibliography contains newly published material in the field of diabetes/metabolism and is divided into 26 sections.
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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography
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The classical hormones, antihormones and maternal disease of the endocrine system discussed in this chapter are distinguished from local tissue factors or mediators, which also include, among other substances, the prostaglandins and leukotrienes.


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    Diabetic medicine : a journal of the British Diabetic Association
  • 2006
Observational data supports the use of metformin in Type 2 diabetes in pregnancy and its role in gestational diabetes is currently under investigation, and the best advice remains that optimized glycaemic control prior to conception and during pregnancy is the most important intervention for best possible pregnancy outcome.
Effects of the oral antidiabetic repaglinide on the reproduction of rats.
Change of the skeleton in the extremities of the offspring were observed in all studies where the animals were exposed to repaglinide during late pregnancy and/or lactation and changes were more pronounced and occurred with a higher incidence as age of offspring increased.
A comparison of glyburide and insulin in women with gestational diabetes mellitus
  • A. Dornhorst
  • Medicine
    Diabetic medicine : a journal of the British Diabetic Association
  • 2001
Treatment of women with gestational diabetes, after the first trimester of pregnancy, with glyburide rather than insulin can achieve similar glycaemic control, with less hypoglycaemia.
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To determine the proportion and nature of congenital anomalies in babies born to women exposed to newly marketed drugs during the first trimester, a large number of them with Down's syndrome are born.
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  • 2004