Use of relatives of cases as controls to identify risk factors when an interaction between environmental and genetic factors exists.

@article{Andrieu1996UseOR,
  title={Use of relatives of cases as controls to identify risk factors when an interaction between environmental and genetic factors exists.},
  author={Nadine Andrieu and Alisa M. Goldstein},
  journal={International journal of epidemiology},
  year={1996},
  volume={25 3},
  pages={
          649-57
        }
}
BACKGROUND The difficulty in detecting relevant risk factors for chronic diseases (such as breast and colon cancer) may be due to heterogeneity in the populations of studied cases, and one source of heterogeneity may be differential genetic susceptibility predisposing to differential environmental sensitivity. METHODS The purpose of this investigation is to determine whether the estimates of odds ratios are modified by using relatives as controls when risk factors interact with an underlying… 
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23 Citations
Background Citations
4
Methods Citations
1
Results Citations
1

23 Citations

Citation Type

Citation Type

Reproductive factors and familial predisposition for breast cancer by age 50 years. A case-control-family study for assessing main effects and possible gene-environment interaction.
TLDR
Findings corroborate results from other studies and provide further evidence that the magnitude of protection from parity is reduced in women most likely to have a genetic risk in spite of the limitations of using surrogate genetic measures.
Epidemiologic and genetic approaches in the study of gene-environment interaction: an overview of available methods.
TLDR
Gene-environment studies are motivated by different situations including the detection of major genes that do not have estimated lifetime risks that reach 100 percent and the identification of gene-environment interaction as a common biologic process in pharmacogenetic studies of complex diseases.
Detection of interaction involving identified genes: available study designs.
TLDR
Approaches to detect gene-environment and gene-gene interactions are reviewed, and most designs allow for estimating risk associated with a genetic factor, environmental factor, and interaction effect.
Interactions between genetic and reproductive factors in breast cancer risk in a French family sample.
TLDR
Interactions between inherited predisposition to BC and reproductive factors were detected here for the first time by segregation analysis and it would be of major interest to confirm these results by family studies in other populations.
Methodological aspects of investigating gene-nutrient interactions.
  • C. Bonaïti‐pellié
  • Biology
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2002
TLDR
The objective of this paper is to review some available methods for evidencing genetic factors and assessing gene–environment interactions, to compare their respective advantages and limitations, and to consider the possible applications to the study of gene–nutrient interactions in colorectal cancer.
Epidemiological approaches to the identification of cancer predisposition genes.
  • T. Rebbeck
  • Biology
    Methods in molecular biology
  • 2003
The goal of appropriate epidemiologic approaches to identify cancer susceptibility genes is to maximize the potential of identifying causal relationships and minimize the potential that spurious…
A Note on a Conditional-Likelihood Approach for Family-Based Association Studies of Candidate Genes
TLDR
It is shown analytically that maximum conditional-likelihood estimators are consistent for the true relative risks, if genotypes for family members are exchangeable under the sampling process, for example, sibling clusters.
16 Genotype-environment interaction in transmission disequilibrium tests
Discovery of cancer susceptibility genes: study designs, analytic approaches, and trends in technology.
TLDR
Many of the main issues related to gene discovery, as well as trends in genomic technology that will impact on gene discovery are discussed from the perspective of their strengths and weaknesses, pointing to areas in need of further work.
Genotype-environment interaction in transmission disequilibrium tests.
TLDR
It is shown that although the genotype-environment correlation caused by the environmental effects of parental alleles on offspring phenotypes can produce spurious marker-phenotype association in population studies, the outcome of TDTs is not biased thereby.
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References

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