Use of recombinant bone morphogenetic protein 2 in free flap reconstruction for osteonecrosis of the mandible.

Abstract

PURPOSE Osteoradionecrosis of the mandible is a debilitating consequence of radiation therapy for head-and-neck malignancy. It can result in pain, bone exposure, fistula formation, and pathologic fracture. Recombinant human bone morphogenetic protein 2 (rhBMP-2) has shown promise in reconstruction of bone defects. The purpose of this study is to determine… (More)
DOI: 10.1016/j.joms.2011.08.037

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