Use of randomization testing to detect multiple epistatic QTLs.

@article{Carlborg2002UseOR,
  title={Use of randomization testing to detect multiple epistatic QTLs.},
  author={Orjan Carlborg and Leif Andersson},
  journal={Genetical research},
  year={2002},
  volume={79 2},
  pages={175-84}
}
Here, we describe a randomization testing strategy for mapping interacting quantitative trait loci (QTLs). In a forward selection strategy, non-interacting QTLs and simultaneously mapped interacting QTL pairs are added to a total genetic model. Simultaneous mapping of epistatic QTLs increases the power of the mapping strategy by allowing detection of interacting QTL pairs where none of the QTL can be detected by their marginal additive and dominance effects. Randomization testing is used to… CONTINUE READING

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