Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study.

@article{Liu2016UseOQ,
  title={Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study.},
  author={Jie Liu and James A Platts-Mills and Jane Juma and Furqan Kabir and Joseph Nkeze and Catherine Bi Okoi and Darwin J. Operario and Jashim Uddin and Shahnawaz Ahmed and Pedro Luis Chas Alonso and Martin Antonio and Stephen Matthew Becker and William C Blackwelder and Robert F. Breiman and Abu S. G. Faruque and Barry S. Fields and J. Michael Gratz and Rashidul Haque and Anowar Hossain and Mohammad Jahangir Hossain and Sheikh Jarju and Farah Naz Qamar and Najeeha Talat Iqbal and Brenda A. Kwambana and Inacio Mandomando and Timothy L. McMurry and Caroline A. Ochieng and John Benjamin Ochieng and Melvin Ochieng and Clayton O. Onyango and Sandra Panchalingam and Adil Kalam and Fatima Aziz and Shahida M. Qureshi and Thandavarayan Ramamurthy and James H. Roberts and Debasish Majumdar Saha and Samba Ousmane Sow and Suzanne E. Stroup and D. Jos{\'e} Octavio Tinajero Zenil Mariano Matamoros Sur and Boubou Tamboura and Mami Taniuchi and Sharon M. Tennant and Deanna Toema and Yukun Wu and Anita K. M. Zaidi and James P Nataro and Karen L. Kotloff and Myron M. Levine and Eric R Houpt},
  journal={Lancet},
  year={2016},
  volume={388 10051},
  pages={1291-301}
}
BACKGROUND Diarrhoea is the second leading cause of mortality in children worldwide, but establishing the cause can be complicated by diverse diagnostic approaches and varying test characteristics. We used quantitative molecular diagnostic methods to reassess causes of diarrhoea in the Global Enteric Multicenter Study (GEMS). METHODS GEMS was a study of moderate to severe diarrhoea in children younger than 5 years in Africa and Asia. We used quantitative real-time PCR (qPCR) to test for 32… CONTINUE READING

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