Use of proton-pump inhibitors in early pregnancy and the risk of birth defects.

@article{Pasternak2010UseOP,
  title={Use of proton-pump inhibitors in early pregnancy and the risk of birth defects.},
  author={B. Pasternak and A. Hviid},
  journal={The New England journal of medicine},
  year={2010},
  volume={363 22},
  pages={
          2114-23
        }
}
BACKGROUND Symptoms of gastroesophageal reflux are common in pregnancy, but there are limited data on the risk of birth defects associated with exposure to proton-pump inhibitors (PPIs) in early pregnancy. METHODS We conducted a cohort study to assess the association between exposure to PPIs during pregnancy and the risk of major birth defects among all infants born alive in Denmark between January 1996 and September 2008. We linked data from nationwide registries, including individual-level… Expand
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