Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats.

@article{Tozaki1998UseOP,
  title={Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats.},
  author={Hideyuki Tozaki and Tomokazu Odoriba and Toru Iseki and Toshio Taniguchi and Takuya Fujita and Masahiro Murakami and Shozo Muranishi and Akira Yamamoto},
  journal={The Journal of pharmacy and pharmacology},
  year={1998},
  volume={50 8},
  pages={913-20}
}
The objective of this study was to examine the effects of protease inhibitors on the absorption of calcitonin from different regions of the intestine in rats. The absorption experiments were investigated by in-situ use of closed intestinal loops in rats and stability of calcitonin was examined in mucosal homogenates and intestinal fluids. The intestinal absorption of calcitonin was evaluated by measurement of its hypocalcaemic effect. No substantial hypocalcaemic response was observed when… CONTINUE READING